Blar i UiS Brage på forfatter "Lorentzen, Marianne"

Viser treff 1-8 av 8

    • Atropisomerism in Tertiary Biaryl 2-Amides: A Study of Ar-CO and Ar-Ar? Rotational Barriers 

      Lorentzen, Marianne; Kalvet, Indrek; Sauriol, Francoise; Rantanen, Toni; Jørgensen, Kåre Bredeli; Snieckus, Victor (Peer reviewed; Journal article, 2017)
      A rotational barrier study was performed on eight tertiary biaryl 2-amides using variable temperature (VT) NMR and exchange (EXSY) spectroscopy experiments. Seven out of the eight 2-amido-2′-methylbiphenyls with additional ...

    • Directed ortho-Metalation and Anionic ortho-Fries Rearrangement of Polycyclic Aromatic O-Carbamates: Regioselective Synthesis of Substituted Chrysenes 

      Kancherla, Sindhu; Lorentzen, Marianne; Snieckus, Victor; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2018-03)
      A general method for the regioselective synthesis of a series of ortho-substituted chrysenyl N,N-diethyl-O-carbamates by the directed ortho-metalation (DoM) strategy is reported. The starting O-carbamates were prepared ...

    • Enantioselective synthesis of (-)-(1R,2R)-1,2-dihydrochrysene-1,2-diol 

      Lorentzen, Marianne; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2014)
      A general chiral building block containing the 1R,2R-trans-diol moiety was constructed utilizing the stereoselective Shi-epoxidation reaction on a tetralone scaffold assembled by a Negishi cross-coupling on N,N-diethylbenzamide. ...

    • Kinase chemodiversity from the Arctic: the breitfussins 

      Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen (Journal article; Peer reviewed, 2019-10)
      In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 ...

    • Regiospecific Photochemical Synthesis of Methylchrysenes 

      Bøhme, Thomas Andre; Egeland, Mari; Lorentzen, Marianne; Mady, Mohamed Fawzy Hamed Attia; Solbakk, Michelle F.; Sæbø, Krister Samsonsen; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2022-12)
      Methylated polycyclic aromatic hydrocarbons (PAHs) are suspected to be some of the toxic compounds in crude oil towards marine life and are needed as single compounds for environmental studies. 1-, 3- and 6-methylchrysene ...

    • Regiospesific synthesis of dimethylphenanthrenes 

      Bøhme, Thomas Andre; Lorentzen, Marianne; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2017-05)
      The dimethylated phenanthrenes 2,3-dimethylphenanthrene (4a), 2,7-dimethylphenanthrene (4b), 2,6-dimethylphenanthrene (4c) and 1,7-dimethylphenanthrene (4d) have been prepared in gram-quantities by a short sequence of ...

    • Synthesis of PAH-metabolites to be used in Environmental Research 

      Lorentzen, Marianne (PhD thesis UiS;191, Doctoral thesis, 2013-04-19)
      As environmental pollutants, polycyclic aromatic hydrocarbons (PAHs) are well known to form metabolites which can react with DNA and proteins to cause mutagenesis and create cancer. For chrysene the metabolite ...

    • Total synthesis of tubastrine and 3-dehydroxy tubastrine by microwave-assisted cross-coupling reactions 

      Lorentzen, Marianne; Bayer, Annette; Sydnes, Magne Olav; Jørgensen, Kåre Bredeli (Journal article, 2015-10)
      The first syntheses of tubastrine and 3-dehydroxy tubastrine are described. The target compounds were prepared in four consecutive steps from commercially available starting materials. The central scaffold was formed by a ...